Wednesday, March 6, 2013

one mechanism

When weight loss slows or plateaus, my instinct is to read all sorts of articles/chapters of books on the subject, just to encourage myself, clean up my "technique" and reinforce my will to succeed.  Thus i often read things online which could be considered just confirmation of what i already know, by way of a pep-talk ... but i never know if i'm going to come across something new or especially-inspiring.  I'm sure i've read a lot of THIS info before, but this time i was ripe to appreciate a particular aspect of it.

One of the (many) ways we see the basic CICO concept fall on its ass is where isocaloric diets differentiating between low- and high-carb arms show significantly different fat-loss results.  And one of the (many) ways low-carb diets "waste" calories lies in the process of gluconeogenesis -- turns out, 100 grams of protein convert to only 57 grams of glucose!  That's some pretty impressive inefficiency!

But that's not the mechanism i was referring to.  The one that "turned on the lights" for me just now is the fact that alcohol use INHIBITS gluconeogenesis.  I had observed that i could still lose weight on my ultra-LC regimen with one glass of wine with brunch and dinner, but beyond that it was (if i may coin a phrase) orvieto-land -- that CITY ON A PLATEAU [evil grin].

I already knew that for the best weight-loss results it helps to stay strictly on the wagon.  Just a reminder, then....

4 comments:

  1. A wagon I've been chasing for the past few months after I fell off due to school stress and the easy availability of a Tim Hortons on campus, of which I've partaken only a few occasions, but which set me up to crave carbs more often. So I started indulging in maple syrup sweetened full-fat greek yogurt, telling myself it was good because it was full-fat, never mind the 2 tbsp of carb-heavy maple syrup I'd add to it, and then chocolate-avocado pudding in the evening (EVERY evening for two weeks). Presently I have a mostly-empty bag of chocolate-covered almonds hiding in my computer drawer.
    I need to jump back on that wagon, push through the carb-flu that's wracking me as I write this, and remember what I used to do when I first started this way of eating, 1.5 years ago. Oh right, I had MENUS on my fridge! I had mantras I told myself over and over again. I was firm, almost zealot-like in my adherence to this new way of eating, which brought me out of a decades-long depression. Oh yeah, and I MOVED! I walked in the mountains. I biked. Now, due to the 2-feet of snow, I ride the bus to school, sit in a classroom, ride the bus back home where I SIT to do my homework. So, I'm going to start getting off BEFORE the school and WALK to the school. This I'm going to do until I can get back on my bike and start biking to school again.
    Seems my new year's reslution came late this year.

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    1. :-) springtime is a much easier time to clean up one's act, though!

      i know how you feel, i think -- it's so easy to do the things that help us COPE when life gets challenging. but eating the higher-carb foods just as an "experiment" completely derails my weight loss, and i feel crummier on top of everything else!

      good luck with your reestablishment of the old successful strategies!!!

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  2. To add to the protein and glucose debate, there was this little study detailing how protein is converted to hepatic glucose output at a rate of about 8%

    I wish they had repeated the experiment for higher doses of protein though, like 100g.

    Dietary Proteins Contribute Little to Glucose Production Even Under Optimal Gluconeogenic Conditions in Healthy Humans.

    http://www.ncbi.nlm.nih.gov/pubmed/23274906

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    1. that's interesting.... it said the subjects were accustomed to a medium sort of dietary protein intake -- you have to wonder if their usual diet was on the high-carb side, because in that situation, surely their livers were full of glycogen and they didn't HAVE to create glucose from the dietary protein, don't you think?

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