One of my link-following adventures led me to THIS paper, which led to THIS magazine article, which i can't read in its entirety for less than thirty bucks.... :-P Aw well, such is life. The abstract probably says the important stuff. (It's got enough acronyms in it -- Kindke might find it worth interpreting for me if he gets bored sometime!)
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J.SourceInstitut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1 Rue Laurent Fries, 67404 Illkirch, France.AbstractWhile bile acids (BAs) have long been known to be essential in dietary lipid absorption and cholesterol catabolism, in recent years an important role for BAs as signalling molecules has emerged. ... Here we show that the administration of BAs to mice increases energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin. This novel metabolic effect of BAs is critically dependent on induction of the cyclic-AMP-dependent thyroid hormone activating enzyme type 2 iodothyronine deiodinase (D2) because it is lost in D2-/- mice. Treatment of brown adipocytes and human skeletal myocytes with BA increases D2 activity and oxygen consumption. ... In both rodents and humans, the most thermogenically important tissues are specifically targeted by this mechanism because they coexpress D2 and TGR5. The BA-TGR5-cAMP-D2 signalling pathway is therefore a crucial mechanism for fine-tuning energy homeostasis that can be targeted to improve metabolic control.
It looks to me as though this may be the secret of the success of Dr. Donaldson's fatty-meat diet, and possibly the Shangri-La (oil-bibbing branch) as well -- it's all about fats which prompt a squirt of bile for our bodies to process. I was "promised" a boost from coconut oil which i never observed to benefit me (although i love the stuff and intend to keep using it generously); this could be the big secret. Coconut oil doesn't require bile for digestion.
It turns out, then, that the fat IN THE MEAT of the Strong Medicine regimen is the trick -- and modern science tells us why. Donaldson clearly stated that dietary fat was important, as he had learned from Vilhjalmur Stefansson (all-lean-meat diet = BAD). As a matter of fact, his suggestion was that if you choose to eat a leaner kind of meat than his recommendations, you should buy extra SUET and chop/grind it into your choice to make it appropriately balanced. As an interesting aside, he observed that most of his patients adapted to a fat-burning metabolism in about five days. Also, his only recommended exercise (except for special stretching for certain conditions) was a daily half-hour walk.
So forget the low-fat diet (as if we haven't already)! Put the coconut oil on the back burner! We've already forgotten heavy exercise and calorie-counting. To lose fat weight and increase our energy, what we need is enough fuel to convince our bodies they can afford to rev up a bit ... and the best fuel of all is good old-fashioned animal fat.
Sure sounds like a LCHF metabolic advantage to me.