I've been a proponent of systemic enzymes for years now. 23andMe may be giving me a hint as to WHY.
It's been established for a long time that one's production of enzymes is generous in childhood through young-adult years, then begins to dwindle after the age of 27. An easily-visible example of this lies in one's wound-healing as one gets older, the writers on this subject tell us -- we get a cut or skinned knee in gradeschool, and after it heals the scar tends to be thin and pliable, but in later life one's scars are thicker, stiffer and more unsightly. I see the difference between pre-supplementing scars and the ones that I've acquired more recently; when Spense bit me six or seven years ago, he really ripped up the skin beside my left thumbnail, but you can't see the traces unless you use a magnifying glass. Not so, for the first scar he gave me!
"Authorities" like Dr. Wm. Wong tell us that this happens inside the body as well as outside: surgeries and other internal insults cause fibrous scar tissue to build up, and our organs' functionality can suffer. Supplemental proteolitic enzymes travel about our bodies cleaning up the excess fibrin that our natural supply did when we were younger. Fibrous plugs in our smaller blood vessels, fibrin thickening our lymphatic fluid, fibrosis in our lungs and other organs, all eaten by the serrapeptase and nattokinase in systemic enzyme supplements....
As a child, my wounds didn't heal as invisibly as some kids' did. Look closely at my knees, and you can see the Ghosts of Bike-Spills Past. When i was about ten, i ruptured my spleen at Girl Scout camp; the surgical scar is bright and clear and well-raised, after all these decades.
And guess what 23andMe reveals -- some risks of fibroid disease (pulmonary) and keloids (and maybe some other fibrosis-related disorders that i don't know enough about to speculate). I should have expected it. But this thing has started me wondering, did i suffer from inadequate endogenous enzyme production in my earliest years perhaps? My old scars would seem to be evidence in that direction.
Whatever the case, i'm inclined to hypothesize that anyone who observes a genetic risk of fibrotic diseases, whether by DNA testing or simply the existence of hypertrophic scarring, would probably benefit from supplementing with a good systemic/proteolytic enzyme! ...Oh, and zinc too (thanks, George!).